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Image Search Results
Journal: Briefings in Bioinformatics
Article Title: A computational toolset for rapid identification of SARS-CoV-2, other viruses and microorganisms from sequencing data
doi: 10.1093/bib/bbaa231
Figure Lengend Snippet: EBV identification using fastv. The EBV genome has a large repetitive region between 12 kb and 35 kb. The coverage result generated by fastv (A) shows even coverage of this region and is similar to the IGV visualization of the BWA alignment result (B). The data used in this experiment was whole genome sequencing of an EBV-positive sample, downloaded from NCBI Sequence Read Archive (SRA accession: ERR1293949).
Article Snippet: The first dataset is the National Center for
Techniques: Generated, Sequencing
Journal: mSystems
Article Title: Metabolic model guided CRISPRi identifies a central role for phosphoglycerate mutase in Chlamydia trachomatis persistence
doi: 10.1128/msystems.00717-24
Figure Lengend Snippet: Overall process of the model reconstruction, refinement, and subsequent analysis/validation. Kbase, NCBI RefSeq, and ModelSEED database were used to reconstruct the initial model. After standard model curations, a high-quality GSM was ready to use. Later, condition-specific transcriptomics data were incorporated with GSM through E-flux algorithm, which resulted in five contextualized models. These models were used to find metabolic bottlenecks and persistence mechanism. K-mean clustering algorithm applied on the transcriptomics data revealed a global stress response mechanism. Thermodynamics and enzyme cost analysis, along with in vitro experimentation, reveal the regulatory role of pgm in CTL persistence.
Article Snippet: To analyze the metabolism of CTL in different stress conditions, we reconstructed a GSM of CTL using the
Techniques: Biomarker Discovery, In Vitro